Facile and Efficient Synthesis of Ethyl 3-oxo-3-(pyridin-4-yl)-2-((pyridin-4-yl)methylene)propanoate

Abstract

The refluxing of ethyl isonicotinate with sodium ethoxide and ethyl acetate yielded the ethyl-3- oxo-3-(pyridin-4-yl)propanoate which was in equilibrium with enol form. The desired product, ethyl 3-oxo-3-(pyridin-4-yl)-2-((pyridin-4-yl)methylene)propanoate was synthesized by the treatment of ethyl-3-oxo-3-(pyridin-4-yl)propanoate and its enolic form with the isonicotinaldehyde under the reflux in neat condition.