Antioxidant Activity and Free Radical Scavenging Properties of Captopril

Abstract

Several diseases are associated with oxidative stress caused by free radicals and reactive oxygen species. In this study, antioxidant activity of captopril was studied using in vitro assays systems. Free radical scavenging and reducing power were determined with diphenyl picryl hydrazyl free radical (DPPH method) and potassium ferricyanide method, respectively. The results of this study showed that captopril possessed a significant free radical scavenging and reducing power properties and there were a clear correlation exists between antioxidant activity and concentration of captopril. Percentage of free radical scavenging of captopril was more than 92 % at concentration 0.08 mM.