Synthesis of Some Functionalized Thiazolo[3,2-b][1,2,4]triazoles

Abstract

A facile synthesis of some 6-aminothiazolo[3,2-b][1,2,4]triazole-5-carbonitriles in good yields has been developed through base catalyzed cyclocondensation of 1,2,4-triazole-3-thiones with bromomalononitrile. In case of phenyl derivative, hydrolysis of the cyano group into amide and subsequent cyclocondesation with benzoyl chloride afforded to the novel tricyclic compound 2,6-diphenyl[1,2,4]triazolo-[5',1':2,3][1,3]thiazolo[4,5-d]pyrimidin-8(7H)-one.