Synthesis, Antimicrobial and Antioxidant Evaluation of Some Bis(Indolyl) Methanes Derivatives

Abstract

A series of novel bis(indolyl)methanes (3-13) derivatives were synthesized. Bis(indolyl)methanes were prepared through an integrated process that involves two basic steps, cyclomerization of o-phenyl ethynyl anilines followed by bis-addition with aldehydes. 2-Phenyl indole (2) was used as a starting material for all derivatives of bis(indolyl)methanes. A mechanism for the reaction is proposed. Compound 11 exhibit excellent gram positive antibacterial activity against S. aureus and compound 18 exhibit excellent gram negative antibacterial activity against E. coli. Compound 12 shows good antifungal activity and antioxidant property than other synthetic derivatives compounds.