Microwave Synthesis of New Pyrazolo[3,4-d]pyrimidin-4-ones in Solvent-Free Condition

Abstract

An efficient method for the synthesis of new pyrazolo[3,4-d]pyrimidin-4-ones through heterocyclization reaction of 5-amino-1-phenyl-1H-pyrazole-4-carboxamides with aroyl halides under microwave irradiation in solvent-free condition is described. In comparison with classical conditions the reactions are faster and the yields are higher under microwave irradiation.