Spectrophotometric Determination of Loratadine in Bulk and Pharmaceutical Formulations

Abstract

The present work described the development of a UV spectrophotometric method for estimation of loratadine. A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of loratadine in bulk and pharmaceutical dosage form. An absorption maximum was found to be at 275 nm. The percentage recovery of loratadine ranged from 99.982 to 101.4908 % in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision, limit of detection (LOD), limit of quantitation (LOQ), Sandell's sensitivity, molar absorbtivity, molar extinction coefficient and specificity. Beer's law was obeyed in the concentration range of 4-40 μg/mL having line equation y = 0.0389x + 0.1011 with correlation coefficient of 0.9999.