Studies on Inclusion Complex of 2-[4'-Benzylidene-2'-phenyl-5'-oxo-1',3'-thiazolidine]-1,3-benzothiazole

Abstract

The compound 2-[4'-benzylidene-2'-phenyl-5'-oxo-1',3'-thiazolidine]-1,3-benzothiazole has been synthesized in its pure form. Since the drug is insoluble in polar solvent, its bioacessibility is low. To increase the solubility of the compound, its inclusion complex has been prepared with β-cyclodextrin. The formation of inclusion complex has been ascertained by study of spectral characteristic before and after inclusion complex formation. The stability of inclusion complex and nature of interaction between the host and guest are known from the study of thermodynamic parameters like change in free energy, change in enthalpy and change in entropy. The study of antimicrobial properties (antibacterial and antifungal) of the compound increases significantly after inclusion complex formation.