4-Acetyl-N,N-dibenzylbenzenesulfonamide in Heterocyclic Synthesis: Synthesis and Biological Evaluation of Novel Sulfonamides Incorporating Thiazole, Pyrazolo[1,5- a]pyrimidine, 4-Oxothiazolidine and 1,3,4-Thiadiazole moieties

Abstract

This article describes the synthesis of some novel sulfonamide containing biologically active, pyridine 2, 4; hydrazine carbothioamide 5, 10; thiazole 6-8, 12-14; hydrazine carbodithioate 9, 11a-c; pyrazolo[1,5-a]pyrimidine 19; 4-oxothiazolidine 22, 24-26, 36, 37, 39, 40, 43, 44 and 1,3,4-thiadiazole 35 moieties starting with 4-acetyl-N,N-dibenzylbenzenesulfonamide 1. The structure of the newly synthesized compounds was confirmed by elemental analysis, IR, ¹H NMR and mass spectral data. All the newly synthesized compounds were evaluated for their in vitro antimicrobial activities against gram positive bacteria (B. subtilis, S. aureus, S. maxima), gram negative bacteria (K. pneumonia, Salmonella, P. aeruginosa) and filamentous fungi (Rhizopus, A. fumigatus). Most of the screened compounds showed interesting highly active compared to ampicillin (AMD) and calforan.