A Facile Route for Synthesis of Structural Analogs for Latanoprost: An Anti-Glaucoma Agent
Corresponding Author(s) : H. Rama Mohan
mohan.hindupur@aptuitlaurus.com
Asian Journal of Chemistry,
Vol. 23 No. 7 (2011): Vol 23 Issue 7
Abstract
A facile synthetic approach has been developed for latanoprost analogs, (±) 13,14-dehydro latanoprost (2), (±) 16-nor-13,14-dehydro latanoprost (3) and (±) 16-homo-13,14-dehydro latanoprost (4) in five steps starting from key intermediate (5), through Wittig reaction and separation of diasteromers as the key steps.
Keywords
Prostaglandins
Anti-glaucoma
, (±) 13,14-Dehydro latanoprost
(±) 16-Nor-13,14- dehydro latanoprost and (±) 16-Homo-13
14-dehydro latanoprost
Harikrishna, M., Rama Mohan, H., Dubey, P., Shankar, M., & V. Subbaraju, G. (2011). A Facile Route for Synthesis of Structural Analogs for Latanoprost: An Anti-Glaucoma Agent. Asian Journal of Chemistry, 23(7), 3121–3126. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10554
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