A Facile Route for Synthesis of Structural Analogs for Latanoprost: An Anti-Glaucoma Agent

M. Harikrishna; H. Rama Mohan; P.K. Dubey; M. Shankar; Gottumukkala V. Subbaraju

Issue

Vol. 23 No. 7 (2011): Vol 23 Issue 7

Issue Published : 11 March 2011

A Facile Route for Synthesis of Structural Analogs for Latanoprost: An Anti-Glaucoma Agent

M. Harikrishna

Aptuit Laurus Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad500 078, India

H. Rama Mohan

Aptuit Laurus Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad500 078, India

P.K. Dubey

Department of Chemistry, College of Engineering, Jawaharlal Nehru Technological University, Hyderabad-500 072, India

M. Shankar

Aptuit Laurus Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad500 078, India

Gottumukkala V. Subbaraju

Lakshmi Surya, A-16, Nalanda Nagar, Tirupati-517 502, India

Corresponding Author(s) : H. Rama Mohan

mohan.hindupur@aptuitlaurus.com

Asian Journal of Chemistry, Vol. 23 No. 7 (2011): Vol 23 Issue 7
Article Published : 24 March 2011

Abstract

A facile synthetic approach has been developed for latanoprost analogs, (±) 13,14-dehydro latanoprost (2), (±) 16-nor-13,14-dehydro latanoprost (3) and (±) 16-homo-13,14-dehydro latanoprost (4) in five steps starting from key intermediate (5), through Wittig reaction and separation of diasteromers as the key steps.

Keywords

Prostaglandins Anti-glaucoma , (±) 13,14-Dehydro latanoprost (±) 16-Nor-13,14- dehydro latanoprost and (±) 16-Homo-13 14-dehydro latanoprost

(1)

Harikrishna, M.; Rama Mohan, H.; Dubey, P.; Shankar, M.; V. Subbaraju, G. A Facile Route for Synthesis of Structural Analogs for Latanoprost: An Anti-Glaucoma Agent. ajc 2011, 23, 3121-3126.

Issue

Vol. 23 No. 7 (2011): Vol 23 Issue 7

A Facile Route for Synthesis of Structural Analogs for Latanoprost: An Anti-Glaucoma Agent

Corresponding Author(s) : H. Rama Mohan

Abstract

Keywords

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