Microwave Synthesis of β-Uramino Crotonic Ester and its Derivatives

Abstract

The new and rapid synthesis of β-uramino crotonic ester and its derivatives involves the condensation of ethyl acetoacetate and urea, thiourea and 1,3-dimethyl urea in presence of ethanol. These compounds are important intermediates for the synthesis of 6-methyl pyrimidinedione derivatives, which are biologically active compounds used in medicinal and pharmaceutical chemistry. The structure of the synthesized compounds has been elucidated with spectral analysis: UV, FTIR and GC-MS.