Facile Preparation of the Synthon of 7-Ethyl-8-oxabicyclo[4.3.0]nonane-2,9-dione
Corresponding Author(s) : Li-Zhen Fang
2002flz@163.com
Asian Journal of Chemistry,
Vol. 23 No. 7 (2011): Vol 23 Issue 7
Abstract
The useful synthon of 7-ethyl-8-oxabicyclo[4.3.0]2,9-dioxononane was readily synthesized by a facile method. Starting from ethyl-1-bromo-2-oxocyclohexane- carboxylate, the 7-ethyl-8- oxabicyclo[4.3.0]nonane-2,9-dione was obtained by subsequent reactions of elimination, addition and reduction in total 49.4% yield. It showed no significant cytotoxicity to Bel7402 in the preliminary cytotoxicity assay study.
Keywords
Michael addition
Bromination
7-Ethyl-8-oxabicyclo[4.3.0]nonane-2,9-dione
Ketoester
Fang, L.-Z., Li, Y.-H., Liu, J.-P., & Yan, F.-L. (2011). Facile Preparation of the Synthon of 7-Ethyl-8-oxabicyclo[4.3.0]nonane-2,9-dione. Asian Journal of Chemistry, 23(7), 2919–2921. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10527
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