Synthesis of New 3-Phenyl-2-thioquinazoline Derivatives

Omar M. Ali; Farag A. El-Essawy; Wael A. El-Sayed; Eman Roushdy; Adel A-H. Abdel-Rahman

Issue

Vol. 23 No. 7 (2011): Vol 23 Issue 7

Issue Published : 11 March 2011

Synthesis of New 3-Phenyl-2-thioquinazoline Derivatives

Omar M. Ali

Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt ; Faculty of Medical and Applied Science, Taif University, Turabah, Taif, Kingdom of Saudi Arabia

Farag A. El-Essawy

Department of Photochemistry, National Research Center, El Dokki, Cairo, Egypt

Wael A. El-Sayed

Department of Photochemistry, National Research Center, El Dokki, Cairo, Egypt

Eman Roushdy

Department of Photochemistry, National Research Center, El Dokki, Cairo, Egypt

Adel A-H. Abdel-Rahman

Department of Photochemistry, National Research Center, El Dokki, Cairo, Egypt

Corresponding Author(s) : Omar M. Ali

omali_66@hotmail.com

Asian Journal of Chemistry, Vol. 23 No. 7 (2011): Vol 23 Issue 7
Article Published : 22 March 2011

Abstract

A new 3-phenyl-2-thioquinazoline derivatives have been synthesized by the reaction of hydrazide 1 with formic acid and diethylmalonate to give 2 and 3, respectively. Compound 1 is reacted with sugar to give the sugar hydrazone (4a-c) which is converted to oxadiazole derivatives (5a-c). The final compounds (6a-c) were obtained by reacting the hydrazones 4a-c with acetic anhydride in pyridine.

Keywords

Synthesis 3-Phenyl-2-thioquinazoline derivatives Sugar hydrazone

(1)

M. Ali, O.; A. El-Essawy, F.; A. El-Sayed, W.; Roushdy, E.; A-H. Abdel-Rahman, A. Synthesis of New 3-Phenyl-2-Thioquinazoline Derivatives. ajc 2011, 23, 2915-2918.

Issue

Vol. 23 No. 7 (2011): Vol 23 Issue 7

Synthesis of New 3-Phenyl-2-thioquinazoline Derivatives

Corresponding Author(s) : Omar M. Ali

Abstract

Keywords

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