Synthesis, Spectral and Antimicrobial Studies of Metal Complexes of Chlorphenoxamide

Abstract

5-Chloromethyl-8-quinolinol hydrochloride was condensed with 2-[(2,2-dichloroethyl)(4-(4- nitrophenoxy)benzyl)amino]ethanol in presence of potassium carbonate. The resulting 5-((2- ((2,2-dichloroethyl)(4-(4-nitrophenoxy)benzyl)amino)ethoxy)methyl)quinolin-8-ol was characterized by elemental analysis and spectral studies. The transition metal chelates of this ligand were prepared with Cu²⁺, Ni²⁺, Co²⁺, Mn²⁺ and Zn²⁺ and characterized by IR and electronic spectral studies and magnetic properties. The antimicrobial activity of ligand and its metal chelates were screened against various gram positive (+) and gram negative (–) organism. The results show that all these samples are more or less active agents against various organisms.