Synthesis and Antibacterial Activity of Some Novel Pyrimidines and Piperidinyl Acetamides

Abstract

1-[4-(4-Benzylpiperidin-1-yl)phenyl]ethanone on condensation with aryl aldehydes afforded 1- [4-(4-benzylpiperidin-1-yl)phenyl]-3-substituted phenyl prop-2-en-1-one (1a-e) in good yields which underwent cyclization with guanidine hydrochloride (2) furnished 4-[4-(4-benzylpiperidin- 1-yl)phenyl]-6-substituted phenyl pyrimidin-2-amine (3a-e) followed by reaction with chloroacetyl chloride (4) in the presence of triethyl amine yielded N-4-[4-(4-benzylpiperidin-1- yl)phenyl]-6-substituted phenyl pyrimidin-2-yl)-2-chloroacetamide (5a-e). The compound N- 4-(4-(4-benzylpiperidin-1-yl) phenyl)-6-substituted phenyl pyrimidin-2-yl)-2-(piperidin-1- yl)acetamide (7a-e) has been prepared by treatment of piperdine, dry acetone and anhydrous potassium carbonate. The structures of the above synthesized new compounds were established by spectral data. All the new compounds have been screened for their antibacterial activity.