Synthesis Characterization and Antifungal Activity of Trivalent and Tetravalent Metal/Non-metal Derivatives of N-(2-Methyl)phenylglycine

Abstract

The trivalent (boron, aluminium, iron, arsenic and antimony) and tetravalent (silicon, titanium and selenium) metal/non-metal derivatives of N-(2-methyl)phenylglycine have been prepared by the interaction of their corresponding isopropoxide with the N-(2-methyl)phenylglycine in 1:1, 1:2, 1:3 and 1:4 molar ratios in benzene medium. The course of reaction was monitored by estimating the amount of isopropanol liberated in benzene-isopropanol azeotrope in each case. The compounds thus prepared were generally obtained as coloured solids and amongst them those containing isopropoxy group(s) was found to be hygroscopic. All these compounds were characterized by azeotrope and elemental analysis, as well as by spectral measurements. They were tested in vitro for their antifungal activity against Aternaria alternate and Fusarium oxyporum.