Synthesis of 1-Benzyl-4-[2-(5-phenyl-1,3,4-thiadiazole-2-yl)aminoethyl]piperidine as Potential Alzheimer's Disease Modifying Agent
Diba Nabardi Sarkandi
Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Loghman Firoozpour
Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
Ali Asadipour
Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
Vahid Sheibani
Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
Mahsa Alizadeh Monavar Asli
Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Asghar Davood
Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Abbas Shafiee
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
Alireza Foroumadi
Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran ; Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
Corresponding Author(s) : Alireza Foroumadi
aforoumadi@yahoo.com
Asian Journal of Chemistry,
Vol. 23 No. 6 (2011): Vol 23 Issue 6
A number of pharmacological agents are available for clinical use in the treatment of alzheimer's disease. The cognitive impairment associated with alzheimer's disease is characterized by reduced levels of acetylcholine in CNS. Acetyl cholinesterase inhibitors increase the level of acetyl choline at the synapses by blocking the breakdown of the neurotransmitter. The aim of this study is the synthesis of 1-benzyl-4-[2-(5-phenyl-1,3,4-thiadiazole-2-yl)aminoethyl]piperidine, as potential acetyl cholinesterase inhibitor, from the reaction of 2-chloro-5-phenyl-1,3,4- thiadiazole and 1-benzyl(piperidin-4-yl)ethylamine. The structure of obtained compound was identified by its 1H NMR, mass and IR spectra
