Synthesis of 1-Benzyl-4-[2-(3-thienylcarbonylamino)ethyl]piperidine as a Novel Potential Cholinesterase Inhibitor
Mahsa Alizadeh Monavar Asli
Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Loghman Firoozpour
Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
Vahid Sheibani
Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
Diba Nabardi Sarkandi
Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Amirhossein Sakhteman
Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Asghar Davood
Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Abbas Shafiee
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
Alireza Foroumadi
Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran ; Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
Corresponding Author(s) : Alireza Foroumadi
aforoumadi@yahoo.com
Asian Journal of Chemistry,
Vol. 23 No. 6 (2011): Vol 23 Issue 6
Potentiating of cholinergic activity which increases the acetylcholine level in the brain has been regarded as an approach for the palliative treatment of alzheimer's disease. Accordingly, inhibition of the acetyl cholinesterase enzyme is considered to be a viable and attractive therapeutic strategy for alzheimer's disease patients. In an attempt to find a new acetyl cholinesterase inhibitor (AChEI), 1-benzylpiperidin-4-yl-ethylamine has been reacted with thiophen-3-carbonylchloride to prepare 1-benzyl-4-[2-(3-thienylcarbonyl-amino)ethyl]piperidine, as potential acetyl cholinesterase inhibitor. The structure of target compound was confirmed by mass, NMR and IR spectra.
Alizadeh Monavar Asli, M., Firoozpour, L., Sheibani, V., Nabardi Sarkandi, D., Sakhteman, A., Davood, A., … Foroumadi, A. (2011). Synthesis of 1-Benzyl-4-[2-(3-thienylcarbonylamino)ethyl]piperidine as a Novel Potential Cholinesterase Inhibitor. Asian Journal of Chemistry, 23(6), 2487–2490. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10451
