Synthesis, Spectral Studies, Antimicrobial Activity and Crystal Structures of Phosphaza-Lariat Ethers

Abstract

Phosphaza-lariat ethers, which are known as 2,2-[4,4'-(2,2'-oxybis(ethane-2,1- diyl)bis(oxy))dianilino]-4,4,6,6-tetrachlorocyclo-2l⁵,4l⁵,6l⁵-triphosphazatriene(spiro) (1), 2,2- [4,4'-(2,2'-(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(oxy)dianilino]-4,4,6,6- tetrachlorocyclo-2l⁵,4l⁵,6l⁵-triphosphazatriene(spiro) (2) and 2,2-[4,4'-(2,2'-(ethane-1,2- diylbis(oxy))bis(ethane-2,1-diyl))bis(oxy)dianilino]-4,4-bis(tert-butylamino)-6,6-dichlorocyclo- 2l⁵,4l⁵,6l⁵-triphosphazatriene (3) have been synthesized. The structures of the compounds (1, 2 and 3) are characterized by elemental analysis, IR, ¹H, ¹³C, ³¹P NMR and mass spectroscopic techniques. The antimicrobial activities of the compounds have been screened in vitro against the organisms. The structures of the compounds 1, 2 and 3 have also been examined by means of cyrstallographically. The compounds 1, 2 and 3 crystallize in the orthorhombic space group Pbca, hexagonal space group P4₃2₁2 and tetragonal space group P4₂/n, respectively. They have unit cell parameters: a = 15.607(1), 10.6723(2) and 26.0308(9), b = 15.667(2), 10.6723(2) and 26.0308(9), c = 19.481(3), 23.3633(6) and 10.6033(4) Å, V = 4763.4(1), 2661.03(1) and 7184.8(4) Å3, D_x = 1.570, 3.031 and 1.258 g cm^-3 and Z = 8, 8 and 8, respectively.