Synthesis of Substituted Chromone Derivatives as Potent Antimicrobial Agents

Abstract

Substituting heteroaryl group in C-2 position of chromone improves the biological activity of flavones. Thus, 2-(1H-indol-3-yl)-4Hchromen- 4-one derivatives (6a-e) and 2-(2-chloroquinolin-3-yl)-4H-chromen-4-one derivatives (7a-e) were synthesized from corresponding chalcone. They were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active antibacterial agent was 2-(1Hindol- 3-yl)-5,7-dimethoxy-4H-chromen-4-one (6e) while 2-(2-chloroquinolin-3-yl)-6-methoxy-4H-chromen-4-one (7b) appeared to be the most active antifungal agent.