Synthesis, Characterization and Antifungal Activity of Some New 5-Substituted 1,3,4-oxadiazole-2-thiols
Aurangzeb Hasan1
1Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur-50603, Malaysia
2Department of Chemistry, Faculty of Science, Quaid-i-Azam University, Islamabad-45320, Pakistan
*Corresponding author: Fax: +60 379674193; Tel: +60 379675165; E-mail: flavonoids@hotmail.com; aurangzeb@um.edu.my
Shelly Gapil1
1Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur-50603, Malaysia
2Department of Chemistry, Faculty of Science, Quaid-i-Azam University, Islamabad-45320, Pakistan
*Corresponding author: Fax: +60 379674193; Tel: +60 379675165; E-mail: flavonoids@hotmail.com; aurangzeb@um.edu.my
Izzat Khan2
1Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur-50603, Malaysia
2Department of Chemistry, Faculty of Science, Quaid-i-Azam University, Islamabad-45320, Pakistan
*Corresponding author: Fax: +60 379674193; Tel: +60 379675165; E-mail: flavonoids@hotmail.com; aurangzeb@um.edu.my
Asian Journal of Chemistry,
Vol. 23 No. 5 (2011): Vol 23 Issue 5
A series of 5-substituted 1,3,4-oxadiazol-2-thiols (3a-i) was synthesized by refluxing variably substituted organic acids (Ra-i) with methanol to the corresponding esters (1a-i). These esters were then converted to hydrazides (2a-i) by reaction with hydrazine hydrate in the presence of absolute ethanol which was followed by reaction with carbon disulfide and potassium hydroxide. Structure of the synthesized compounds was established by physicochemical and spectral data analysis. Synthesized compounds were subjected to antifungal activity. Antifungal activity was performed against Aspergillus flavus, Mucor species, Aspergillus niger and Aspergillus fumigates, with test compounds at a concentration of 200 μg/mL. Terbinafine was used as the standard drug.
Keywords
Synthesis134-oxadiazoleAntifungal activity.
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Hasan1, A., Gapil1, S., & Khan2, I. (2011). Synthesis, Characterization and Antifungal Activity of Some New 5-Substituted 1,3,4-oxadiazole-2-thiols. Asian Journal of Chemistry, 23(5), 2007–2010. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10358