Aldose Reductase and a-Glycosidase Inhibition Activities of Active Fraction of Leucaena leucocephala (lmk) De Wit Seeds
Ros Sumarny1
1Department of Pharmacology, Faculty of Pharmacy, Pancasila University. Jl. Srengseng Sawah, Jagakarsa, South Jakarta, Indonesia
2Research Centre for Biotechnology, Indonesian Institute of Science, Jln. Raya Bogor Km 46, Cibinong 16911, Indonesia
*Corresponding author: Fax: +62 21 7864727 21; Tel: +62 21 7864728; E-mail: syamsudin27@yahoo.com
Partomuan Simanjuntak2
1Department of Pharmacology, Faculty of Pharmacy, Pancasila University. Jl. Srengseng Sawah, Jagakarsa, South Jakarta, Indonesia
2Research Centre for Biotechnology, Indonesian Institute of Science, Jln. Raya Bogor Km 46, Cibinong 16911, Indonesia
*Corresponding author: Fax: +62 21 7864727 21; Tel: +62 21 7864728; E-mail: syamsudin27@yahoo.com
Asian Journal of Chemistry,
Vol. 23 No. 5 (2011): Vol 23 Issue 5
The fraction of methanolic extract of Leucaena leucocephala (lmk) De Wit seeds was found to showed inhibitory activities on a-glucosidase and aldose reductase, respectively. The assays of aldose reductase and a-glycosidase inhibition activities were conducted in in vitro way on the subfractions isolated from the methanol extract of Leucaena leucocephala (lmk) De Wit. This work shows that one of the active subfractions (I-5) can inhibit aldose reductase and a-glycosidase enzyms, with the IC50 of 12.56 ± 1.23 μg/mL dan 7.67 ± 1.32 μg/mL. These IC50 values of I-5 are on par with acarbose.
Keywords
Aldose reductasea-GlycosidaseLeucaena leucocephala (lmk) De Wit seedsDiabetes mellitus.
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Sumarny1, R., & Simanjuntak2, P. (2011). Aldose Reductase and a-Glycosidase Inhibition Activities of Active Fraction of Leucaena leucocephala (lmk) De Wit Seeds. Asian Journal of Chemistry, 23(5), 2223–2224. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10331
