Synthesis, Spectroscopic Characterization and Antibacterial Screening of Novel N-(Benzothiazol-2-yl)ethanamides
L.N. Obasi1
1Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Nigeria
2Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria
3Department of Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria
*Corresponding author: E-mail: nnamdi.obasi@unn.edu.ng; obasinl@yahoo.com
P.O. Ukoha1
1Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Nigeria
2Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria
3Department of Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria
*Corresponding author: E-mail: nnamdi.obasi@unn.edu.ng; obasinl@yahoo.com
K.F. Chah2
1Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Nigeria
2Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria
3Department of Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria
*Corresponding author: E-mail: nnamdi.obasi@unn.edu.ng; obasinl@yahoo.com
A.O. Anaga3
1Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Nigeria
2Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria
3Department of Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria
*Corresponding author: E-mail: nnamdi.obasi@unn.edu.ng; obasinl@yahoo.com
Asian Journal of Chemistry,
Vol. 23 No. 5 (2011): Vol 23 Issue 5
Synthesis, electronic, infrared, elemental micro analytical studies were carried on N-(benzothiazol-2-yl)trichloroethanamide (4) and N- (benzothiazol-2-yl)chloroethanamide (5). They were also screened in vitro and in vivo for antibacterial activity. The results indicate that the compounds are stable and that they show high antibacterial activities against both gram-positive and gram-negative bacteria tested. Both derivatives of 2-aminobenzothiazole were active against the multiresistant bacteria with diameter of inhibition zone ranging from 9-18 mm (5) and 9-20 mm (4). From the MIC results it is observed that the [5] derivative produced a better antibacterial activity than the (4) derivative. The lethal concentrations (LC50) of the compounds were also determined. Their solubilities and melting points were also determined.
Obasi1, L., Ukoha1, P., Chah2, K., & Anaga3, A. (2011). Synthesis, Spectroscopic Characterization and Antibacterial Screening of Novel N-(Benzothiazol-2-yl)ethanamides. Asian Journal of Chemistry, 23(5), 2043–2045. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10285