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Synthesis and Antimicrobial Evaluation of Some 4-Thiazolidinone Derivatives Containing Polynuclear Hydrocarbon
Corresponding Author(s) : Neelam Verma
Asian Journal of Chemistry,
Vol. 28 No. 11 (2016): Vol 28 Issue 11
Abstract
Some 4-thiazolidinone derivatives have also been known to be associated with several biological activities thus can be utilized as promising scaffold for developing analogues. Aryl aldehydes were treated with naphthylamine to yield corresponding Schiff’s bases. The Schiff’s bases were treated with thioacetic acid in the presence of anhydrous ZnCl2 to afford 4-thiazolidinone derivatives then all the compounds were characterized and evaluated for antibacterial and antifungal activity. Compounds having methoxy group at meta- and para-position, dimethylamino and hydroxyl group at para-position was found to be biologically active.
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- C.G. Warmath, The Practice of Medicinal Chemistry, edn 2, p. 69 (2004).
- M.R. Manrao, R.K. Sethi, R.C. Sharma and P.S. Kalsi, J. Indian Chem. Soc., 73, 695 (1996).
- R. Yadav, S.D. Srivastava and S.K. Srivastava, Indian J. Chem., 44B, 1262 (2005).
- D.P. Mehta, N.P.S. Sengar and A.K. Pathak, Oreint. J. Chem., 24, 441 (2008).
- P.N. Patel and Y.S. Patel, Cogent Chem., 1, 1048558 (2015); doi:10.1080/23312009.2015.1048558.
- M.M. Hania, E-J. Chem., 6, 629 (2009).
- H. Behbehani and H.M. Ibrahim, Molecules, 17, 6362 (2012); doi:10.3390/molecules17066362.
- Indian Pharmacopoeia, Ministry of Health and Family Welfare; Published by Controller of Publications, New Delhi; A101, vol. II (1996).
- N.S. Ncube, A.J. Afolayan and A.I. Okoh, Afr. J. Biotechnol., 7, 1797 (2008); doi:10.5897/AJB07.613.
- J.M. Andrews, J. Antimicrob. Chemother., 48(suppl 1), 5 (2001); doi:10.1093/jac/48.suppl_1.5.
- M. Sultana, S. Arayne and H. Furkan, Pak. J. Pharm. Sci., 18, 59 (2005).
- M. Chutia, P.D. Bhuyan, M.G. Pathak, T.C. Sarma and P. Boruah, LWT-Food Sci. Technol. (Paris), 42, 777 (2009).
References
C.G. Warmath, The Practice of Medicinal Chemistry, edn 2, p. 69 (2004).
M.R. Manrao, R.K. Sethi, R.C. Sharma and P.S. Kalsi, J. Indian Chem. Soc., 73, 695 (1996).
R. Yadav, S.D. Srivastava and S.K. Srivastava, Indian J. Chem., 44B, 1262 (2005).
D.P. Mehta, N.P.S. Sengar and A.K. Pathak, Oreint. J. Chem., 24, 441 (2008).
P.N. Patel and Y.S. Patel, Cogent Chem., 1, 1048558 (2015); doi:10.1080/23312009.2015.1048558.
M.M. Hania, E-J. Chem., 6, 629 (2009).
H. Behbehani and H.M. Ibrahim, Molecules, 17, 6362 (2012); doi:10.3390/molecules17066362.
Indian Pharmacopoeia, Ministry of Health and Family Welfare; Published by Controller of Publications, New Delhi; A101, vol. II (1996).
N.S. Ncube, A.J. Afolayan and A.I. Okoh, Afr. J. Biotechnol., 7, 1797 (2008); doi:10.5897/AJB07.613.
J.M. Andrews, J. Antimicrob. Chemother., 48(suppl 1), 5 (2001); doi:10.1093/jac/48.suppl_1.5.
M. Sultana, S. Arayne and H. Furkan, Pak. J. Pharm. Sci., 18, 59 (2005).
M. Chutia, P.D. Bhuyan, M.G. Pathak, T.C. Sarma and P. Boruah, LWT-Food Sci. Technol. (Paris), 42, 777 (2009).