Factorial Study on the Effects of b-Cyclodextrin and Sodium Lauryl Sulphate on the Solubility and Dissolution Rate of Celecoxib Tablets

Abstract

The objective of the study is to evaluate the individual and combined (or interaction) effects of

b

-cyclodextrin (bCD) and sodium lauryl sulphate (SLS), a surfactant on the solubility and2 factorial study. the solubility of celecoxib in the fourbCD and SLS, as per 22-factorial study, was determined. The solubilitybCD (3.27 fold), SLS (15.84 fold) individually as wellbCD and SLSp < 0.01). Celecoxib tablets were formulated employing selected combinationsbCD and SLS as per a 22 factorial design and were evaluated. The individual mainbCD, SLS and their combined effects in enhancing the dissolution rate of celecoxibp < 0.05). b-Cyclodextrin and SLS alone gave higher enhancement inbCD and SLS was used in the tablets.

dissolution rate of celecoxib tablets in a 2

selected fluids containing

of celecoxib was markedly enhanced by

as in combined form (28.40 fold). Both the individual and combined effects of

were highly significant (

of

effects of

tablets wer significant (

dissolution rate of celecoxib tablets (2.39-2.46 fold). There was no additional increase in the

dissolution rate of celecoxib when a combination of