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Vol. 28 No. 11 (2016): Vol 28 Issue 11

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Ni(II), Cu(II) and Pd(II) Complexes of Anisaldehyde-4-phenyl-thiosemicarbazone: Synthesis, Spectral Characterization and Biological Study

https://doi.org/10.14233/ajchem.2016.20013
Jayantajit Baruah
Department of Chemistry, Dibrugarh University, Dibrugarh-786 004, India
Geetika Borah
Department of Chemistry, Dibrugarh University, Dibrugarh-786 004, India
Devid Kardong
Department of Life Sciences, Dibrugarh University, Dibrugarh-786 004, India

Corresponding Author(s) : Geetika Borah

geetikachem@yahoo.co.in

Asian Journal of Chemistry, Vol. 28 No. 11 (2016): Vol 28 Issue 11

Abstract

Anisaldehyde-4-phenyl-thiosemicarbazone (HL) complexes of Ni(II), Cu(II) and Pd(II) have been synthesized. Conductivity measurements, spectroscopic (FTIR, UV-visible, ESI(+) mass, 13C and 1H NMR, ESR), cyclic voltammetry study and thermal analyses were used to propose their molecular formulations. Ni(II), Cu(II) and Pd(II) complexes show room temperature magnetic moments of 3.07, 1.59 and 0.00 BM, respectively. The ligand and the metal complexes have been screened in vitro for antibacterial activity against the bacterial strains viz. P. vulgaris, S. aureus, E. coli, S. aeruginosa, B. subtillis and S. epidemidis and for antifungal activity against the fungal strains viz. A. niger, F. Oxosporum ciceri, F. oxosporum NCIM1281 and R. solani. The ligand, Cu(II) and Pd(II) complexes have been tested for antitubercular activity against Mycobacterium tuberculosis H37RV strain and for anticancer activity against three human cancer lines. The Cu(II) complex was found to be most potent against M. tuberculosis H37RV strain and showed its MIC as 10 μM. The ligand and Cu(II) complex exhibited quite good growth inhibitory activity against most of the tested bacterial and fungal strains.

Keywords

Anisaldehyde-4-phenyl-thiosemicarbazone Antibacterial Antifungal Antitubercular Anticancer activity
Baruah, J., Borah, G., & Kardong, D. (2016). Ni(II), Cu(II) and Pd(II) Complexes of Anisaldehyde-4-phenyl-thiosemicarbazone: Synthesis, Spectral Characterization and Biological Study. Asian Journal of Chemistry, 28(11), 2446–2452. https://doi.org/10.14233/ajchem.2016.20013
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