Novel and Improved Process for the Preparation of Citalopram
Corresponding Author(s) : V. Usharani
uvattikuti@yahoo.co.in
Asian Journal of Chemistry,
Vol. 23 No. 4 (2011): Vol 23 Issue 4
Abstract
A novel process for the preparation of citalopram (1) has been described. The key intermediate 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (2) of citalopram is prepared using novel intermediates. The process involves simple acylation, hydrolysis and reduction, which can be easily adapted to commercial scale.
Keywords
Citalopram hydrobromide
Acylation
Hydrolysis and reduction
(1)
Pulla Reddy, M.; Bhujanga Rao, A.; Usharani, V.; Dubey, P. Novel and Improved Process for the Preparation of Citalopram. ajc 2010, 23, 1829-1832.
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX