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Vol. 23 No. 4 (2011): Vol 23 Issue 4

Facile and Selective Synthesis of 2,3,4,5-Tetrafluorobenzoyl Chloride with Triphosgene

Juhong Yang
Department of Applied Chemistry, College of Food Science & Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou 310035, P.R. China ; Zhejiang Medical College, Hangzhou 310053, P.R. China
Xiaoxiang Han
Department of Applied Chemistry, College of Food Science & Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou 310035, P.R. China
Lingxiao Zhou
Department of Applied Chemistry, College of Food Science & Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou 310035, P.R. China
Chunhua Xiong
Department of Applied Chemistry, College of Food Science & Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou 310035, P.R. China

Corresponding Author(s) : Xiaoxiang Han

han-xx74@163.com; hxx74@126.com

Asian Journal of Chemistry, Vol. 23 No. 4 (2011): Vol 23 Issue 4

Abstract

The method of 2,3,4,5-tetrafluorobenzoyl chloride synthesis with triphosgene was studied. High catalytic activity and the yield of carbonyl chloride on the chlorination of acid were achieved. The yield could be reached 95 mol % when the catalyst (DMF) was 5 mol % of acid, 1,2- dichloroethane used as solvent, n(triphosgene):n(acid) value 0.37:1.00 and the reaction was carried out at 353 K for 4 h.

Keywords

Triphosgene 2,3,4,5-Tetrafluorobenzoic acid 2,3,4,5-Tetrafluorobenzoyl chloride
Yang, J., Han, X., Zhou, L., & Xiong, C. (2010). Facile and Selective Synthesis of 2,3,4,5-Tetrafluorobenzoyl Chloride with Triphosgene. Asian Journal of Chemistry, 23(4), 1615–1617. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10221
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