Synthesis, Characterization and Biological Studies of Organotin(IV) Thiocarbamates

Abstract

Organotin(IV) derivatives of dithiocarbamic acid having the general formula R₂SnL₂ and R₃SnL have been prepared by reacting 1-(2-pyridyl)piperazinedithiocarbamic acid and organotin(IV) chloride in stoichiometric amount in dry ethanol. These compounds have been characterized by IR, multinuclear NMR (¹H, ¹³C, ¹¹⁹Sn) spectral analyses. The spectroscopic data revealed that triorganotin(IV) derivatives are four-coordinated in non-coordinating solvent and have fivecoordinated polymeric geometry around the tin in solid state. Diorganotin dithiocarbamates are found to be penta-coordinating in non-coordinating solvent. While in solid state geometry around tin may be hexa-coordinated. These compounds have also been screened for bactericidal and fungicidal activities. LD₅₀ data have also been collected by Brine-Shrimp lethality bioassay method.