Factorial Study to Evaluate the Individual and Combined Effects of Cyclodextrins and Tween 80 on the Solubility and Dissolution Rate of Aceclofenac

Abstract

The objective of the study is to evaluate the individual main effects and combined (or interaction)

effects of two cyclodextrins [

b-cyclodextrin (bCD) and hydroxypropyl-b-cyclodextrin (HPbCD)]2

factorial experiments. The solubility of aceclofenac in purified water (1), water containing 5

mM of cyclodextrins (

containing 5 mM of CDs (

factorial design. The individual and combined effects of

enhancing the solubility of aceclofenac were highly significant (

aceclofenac was markedly enhanced by

fold) individually as well as combindly by

fold). Solid inclusion complexes of aceclofenac-cyclodextrins (

with and without Tween 80 as per 2

of aceclofenac from the cyclodextrin complexes prepared was studied in phosphate buffer of pH

6.8 (n = 4). Cyclodextrins alone gave higher enhancement in the dissolution rate and DE

aceclofenac. The individual main effect of cyclodextrins (

effect of cyclodextrins and Tween 80 in enhancing the dissolution rate and DE

significant (

a combination of

solubility and dissolution rate of aceclofenac.

bCD or HPbCD) (a), water containing 2 % Tween 80 (b) and waterbCD or HPbCD) and 2 % Tween 80 (ab) were determined as per 22bCD, HPbCD and Tween 80 inp < 0.01). The solubility ofbCD (1.57 fold), HPbCD (1.47 fold), Tween 80 (7.91bCD-Tween 80 (10.54 fold) HPbCD-Tween 80 (11.96bCD or HPbCD) were prepared2 factorial design by kneading method. The dissolution rate15 ofbCD and HPbCD) and the combined15 were highlyp < 0.01). Whereas the main effect of Tween 80 was not significant (p > 0.05). Thus,bCD-Tween 80 and HPbCD-Tween 80 is recommended for enhancing the

and Tween 80, a surfactant on the solubility and dissolution rate of aceclofenac in a series of 2