Microwave Assisted Synthesis and Pharmacological Screening of Novel 6-Methyl-2-oxo- 4-substituted 5-(5-Phenyl-1,3,4-oxadiazole-2-yl)-1,2,3, 4-tetrahydropyrimidines

Abstract

A simple and efficient method has been developed for the synthesis of various 1,3,4-oxadiazole derivatives prepared from DHPM using microwave irradiation technique. The series of 1,3,4- oxadiazole-2-yl-1,2,3,4-tetrahydropyrimidine-2(1H)-one derivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated for there lipoxygenase inhibitory and antibacterial activities. The results showed that this skeletal framework exhibited marked potency as lipoxigenase inhibition and antibacterial agents. The most active lipoxigenase inhibitor and antibacterial agent was 6-methyl-2-oxo-4-(p-nitrophenyl)-5-(5-phenyl-1,3,4-oxadiazole-2-yl)- 1,2,3,4-tetrahydropyrimidine.