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Vol. 23 No. 1 (2011): Vol 23 Issue 1

Aluminium Phosphate Mediated Three-Component Mannich-Type Reaction

K. Srinivas
Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy's Laboratories Limited, Bachupally, Hyderabad-500 072, India
P. Pratap Reddy
Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy's Laboratories Limited, Bachupally, Hyderabad-500 072, India
P. Jayaprakash
Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy's Laboratories Limited, Bachupally, Hyderabad-500 072, India
P.K. Dubey
Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India
A. Kalyan Chakravarthy
Research and Development, Integrated Product Development, Innovation Plaza, Dr. Reddy's Laboratories Limited, Bachupally, Hyderabad-500 072, India

Corresponding Author(s) : A. Kalyan Chakravarthy

kalyanca@drreddys.com

Asian Journal of Chemistry, Vol. 23 No. 1 (2011): Vol 23 Issue 1

Abstract

Aluminium phosphate efficiently catalyzed the one-pot, three-component Mannich-type reaction of acetophenones with aromatic aldehydes and aromatic amines under solvent-free conditions at ambient temperature and afforded the corresponding b-amino carbonyl compounds in good to excellent yields. The present methodology offers several advantages such as mild reaction conditions, shorter reaction times and simple workup procedure.

Keywords

Mannich reaction Aluminium phosphate One-pot synthesis β-Amino ketones Shorter reaction times
Srinivas, K., Pratap Reddy, P., Jayaprakash, P., Dubey, P., & Kalyan Chakravarthy, A. (2010). Aluminium Phosphate Mediated Three-Component Mannich-Type Reaction. Asian Journal of Chemistry, 23(1), 138–140. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10106
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