Synthesis and Anticonvulsant Activity 6-Alkoxy-[1,2,4]triazolo[3,4-a]phthalazin-3(2H)-ones
Corresponding Author(s) : Quan Zhe-Shan
zsquan@ybu.edu.cn
Asian Journal of Chemistry,
Vol. 23 No. 1 (2011): Vol 23 Issue 1
Abstract
A new series of 6-alkoxy-[1,2,4]triazolo[3,4-a]phthalazin-3(2H)-one derivative was synthesized by condensation of appropriate 1-chloro-4-alkoxy phthalazine with methyl hydrazine carboxylate. All the compounds 5a-5r, characterized by IR, 1H NMR and MS, have been evaluated for their anticonvulsant activity against MES-induced seizure. The result illustrats that 6-pentyloxy- [1,2,4]triazolo[3,4-a]phthalazin-3(2H)-one (5b) possessed the most potential anticonvulsant activity.
Keywords
Triazolone
Phthalazine
Anticonvulsant
1,2,4-Triazolo[3,4-a]phthalazine-3(2H)-one
Maximal electroshock
(1)
Cheng-Xi, W.; Zhou, G.; Fu-Nan, L.; Zhe-Shan, Q. Synthesis and Anticonvulsant Activity 6-Alkoxy-[1,2,4]triazolo[3,4-a]phthalazin-3(2H)-Ones. ajc 2010, 23, 127-131.
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