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Vol. 28 No. 11 (2016): Vol 28 Issue 11

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Design, Synthesis and Biological Evaluations of Novel Conjugates of Danshensu, Tetramethylpyrazine and Hydrogen Sulfide Donors as Cardioprotective Agents

https://doi.org/10.14233/ajchem.2016.20101
Chang-Jiang Xu
Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-Cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou 510632, P.R. China
Hui-Xing Deng
Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-Cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou 510632, P.R. China
Hai-Yun Chen
Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-Cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou 510632, P.R. China
Qing-Bin Cui
Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-Cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou 510632, P.R. China
Lu-Chen Shan
Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-Cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou 510632, P.R. China
Pei Yu
Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-Cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou 510632, P.R. China
Ye-Wei Sun
Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-Cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou 510632, P.R. China
Yu-Qiang Wang
Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-Cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou 510632, P.R. China

Corresponding Author(s) : Ye-Wei Sun

stroke126@163.com; 1808332258@qq.com

Asian Journal of Chemistry, Vol. 28 No. 11 (2016): Vol 28 Issue 11

Abstract

A series of molecular hybrids of Danshensu-tetramethylpyrazine-hydrogen sulfide donors have been synthesized and evaluated in vitro as potent antimyocardial ischemia agents. The pharmacological data demonstrated that compound DTA-2 exhibited the most potent protective activities against tert-butyl hydroperoxide (t-BHP) induced injury in H9c2 cells. Further study showed that DTA-2 exhibited better ROS-scavenging activity and mitochondria protective effect than its parental drug DTM, ACS48 and mixtures of these two. These results indicated that DTA-2 may work through a unique mechanism and may serve as a drug candidate for anti-myocardial ischemia therapy that require further study.

Keywords

Danshensu Tetramethylpyrazine H2S donor Synergistic effect Myocardial ischemia/reperfusion injury
Xu, C.-J., Deng, H.-X., Chen, H.-Y., Cui, Q.-B., Shan, L.-C., Yu, P., … Wang, Y.-Q. (2016). Design, Synthesis and Biological Evaluations of Novel Conjugates of Danshensu, Tetramethylpyrazine and Hydrogen Sulfide Donors as Cardioprotective Agents. Asian Journal of Chemistry, 28(11), 2555–2561. https://doi.org/10.14233/ajchem.2016.20101
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