Anticancer Activity of Selective Cyclooxygenase-2 Inhibitor with Conventional NSAIDs
Corresponding Author(s) : Debasis Mishra
Asian Journal of Chemistry,
Vol. 23 No. 1 (2011): Vol 23 Issue 1
Abstract
Cyclooxygenase-2 (COX-2) is frequently detected in colon cancer and is believed to play a crucial role in colorectal carcinogenesis. The incidences of colorectal cancer were 0 % in group A, group B was taken as 100 %, 91 % in group C, 46 % in group D, 71 % in group E and 15 % in group F (p = 0.001, ANOVA). Compared with AOM controls, treatment with etoricoxib 10 mg/kg/day also showed lower ACF count and liver dysplasia. Although there is significantly higher COX-2 expression than their adjacent normal tissues, suggesting that the chemo preventive effect of etoricoxib may be mediated by a COX independent pathway. Treatment with etoricoxib (5 mg/kg) had no significant effect on number of ACF, treatment with etoricoxib (10 mg/kg) reduced colorectal cancer incidence and growth in rats.
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