Synthesis and Biological Evaluation of Novel of 6-(Substituted Phenyl)-2H-imidazo[1,2-a]imidazol-3-one

Abstract

One of the most attractive concept in chemistry for sustainability is green chemistry, which is the utilization of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and applications of chemical product. Microwave heating has attracted the attention of today's research worker. Reactions in microwave are currently in use for synthesis of medicinally important compounds. Within the framework of green chemistry we had synthesized 6-(substituted phenyl)-2H-imidazo[1,2-a]imidazol-3-one by cyclocondensation of 4-(substituted phenyl)-1H-imidazol-2(5H)-one/thione/imine with amino acids using PTC and triethyl benzyl ammonium chloride. Synthesized compounds have been tested for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Salmonella typhi, Proteus vulgaris using cup-plate methodand their minimum inhibitory concentration (MICs) were determined using broth macrodilution method.