Synthesis, Characterization and Antimicrobial Activity of Some New Schiff's Bases Derived from 5-Acetyl-2,6-dimethylpyrimidin-4(3H)-one and Primary Aromatic Amines

Abstract

2,6-Dimethyl-5-[1-(arylimino)ethyl]pyrimidin-4(3H)-one were synthesized from primary aromatic amines and 5-acetyl-2,6-dimethylpyrimidin-4(3H)-one. These were characterized by IR, ¹H NMR, ¹³C NMR and mass spectral analysis. In vitro biological screening effects of the investigated compounds were tested against the bacterial species Staphylococcus aureus, Escherichia coli, Salmonella typhi and Bacillus subtilis by Agar cup method. Fungal species Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme and Aspergillus flavus by the poison plate method.