In-vitro Release of Metformin Hydrochloride from Films of Chitosan-Methylcellulose Blends

Abstract

Films consisting of chitosan and methylcellulose were prepared for in-vitro study of controlled release of metformin hydrochloride.  A viscous solution of chitosan-methylcellulose was prepared in 2 % acetic acid and casted into films. The films were dried at room temperature and crosslinked with glutaraldehyde. Physical characterization of films was carried out and their swelling response to different degree of crosslinking was studied.  The drug release studies through the film indicated that the films can be used as a vehicle for controlled drug release.