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Vol. 37 No. 12 (2025): Vol 37 Issue 12, 2025

Copyright (c) 2025 Archna Talwar, Avni Nayyar, Shruti Anand, Manaal Zahera, Prachi Singh

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Bioconjugated ZnO Nanoparticles from Solanum nigrum Leaves: Monosaccharide Unlocks Potent Antidiabetic and Antioxidant Power

https://doi.org/10.14233/ajchem.2025.34663
Archna Talwar
Department of Chemistry, Isabella Thoburn College, University of Lucknow, Lucknow-226007, India
https://orcid.org/0000-0001-6915-5252
Avni Nayyar
Department of Chemistry, Isabella Thoburn College, University of Lucknow, Lucknow-226007, India
https://orcid.org/0009-0001-5218-7327
Shruti Anand
Department of Chemistry, Isabella Thoburn College, University of Lucknow, Lucknow-226007, India
https://orcid.org/0009-0005-8930-0652
Manaal Zahera
Department of Biotechnology, Era University, Lucknow-226003, India
https://orcid.org/0009-0007-0092-1415
Prachi Singh
Department of Environmental Sciences, Hindu College, University of Delhi, Delhi-110007, India
https://orcid.org/0000-0001-8563-9556

Corresponding Author(s) : Archna Talwar

archna.05talwar@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 12 (2025): Vol 37 Issue 12, 2025

Abstract

The research focuses on conjugating biogenically synthesized zinc oxide nanoparticles (ZnO NPs) with glucose to analyse the inhibitory potential of ZnO nanoparticles against α-amylase. This study proposes, for the first time, that glucose-modified ZnO NPs may alleviate oxidative stress that hinders the formation of advanced glycation end products (AGEs). ZnO NPs are synthesized by using an aqueous leaf extract of Solanum nigrum and characterized using different characterization techniques such as UV-Vis spectroscopy, FESEM, TEM, FTIR, DLS/Zeta and X-ray diffraction. The ZnO NPs were assessed for in vitro antioxidant potential, confirming better antioxidant potential of GC-NP (IC50 = 45.7 ± 0.18 µg/mL) than UC-NP (IC50 = 53.4 ± 0.031 µg/mL). The bio-functionalized ZnO NPs were evaluated for their α-amylase inhibitory activity, showing enhanced inhibition by GC-NP (IC50 = 521 ± 0.004 µg/mL) compared to UC-NP (IC50 = 530 ± 0.01 µg/mL), attributed to tailored surface interactions. Overall, the study highlights that biofunctionalized ZnO NPs exhibit promising potential as a future drug candidate for targeted drug delivery in diabetes management.

Keywords

Green synthesis Solanum nigrum Glucose capping Advanced glycation end products Oxidative stress
(1)
Talwar, A.; Nayyar, A.; Anand, S.; Zahera, M.; Singh, P. Bioconjugated ZnO Nanoparticles from Solanum Nigrum Leaves: Monosaccharide Unlocks Potent Antidiabetic and Antioxidant Power. ajc 2025, 37, 2972-2982.
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