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Vol. 37 No. 1 (2025): Vol 37 Issue 1, 2025

Copyright (c) 2024 S. Syed Ali Fathima, M. Mohamed Sahul Meeran

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Synthesis, Characterization, Biological and in silico ADMET Studies of Mixed Ligand Transition Metal Complexes Based on Novel Schiff Base and 1,10-Phenanthroline

https://doi.org/10.14233/ajchem.2025.32196
S. Syed Ali Fathima
International Research Centre, Department of Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil-626126, India
https://orcid.org/0000-0001-5240-6721
M. Mohamed Sahul Meeran
Jana Marine Service Co. Limited, Al Khobar, Kingdom of Saudi Arabia
https://orcid.org/0009-0000-4629-8576

Corresponding Author(s) : S. Syed Ali Fathima

syed.s@klu.ac.in

Asian Journal of Chemistry, Vol. 37 No. 1 (2025): Vol 37 Issue 1, 2025

Abstract

The main objective of this work is to mitigate the challenges associated with the use of platinum-based chemotherapy drugs through investigating chemotherapeutic compounds based on mixed ligand transition metal complexes. Thus, Cu(II), Co(II), Ni(II) and Zn(II) complexes were synthesized from novel Schiff base compound derived from 2-amino-3-hydroxypyridine and 5-chloro-2-nitrobenzaldehyde and the co-ligand 1,10-phenanthroline. The spectral investigations were conducted to characterize the synthesized compounds and revealed that they possess an octahedral structure. The interactions of synthesized compounds with calf thymus DNA (ct-DNA) demonstrated that the binding takes place through an intercalation. Comparatively to Schiff base ligand, the synthesized transition metal complexes proved to be better anti-pathogenic agent when tested against bacteria. The prepared compounds possess more the biological capability, according to in silico ADMET study, which may attributed to the presence of two N-heterocyclic ligands. The computational screening of biological activities related to cancer activity using PASS software propose the drug-like nature of the compounds.

Keywords

Mixed ligand complexes Schiff base 1,10-Phenanthroline DNA Anticancer potential ADMET
Fathima, S. S. A., & Meeran, M. M. S. (2024). Synthesis, Characterization, Biological and in silico ADMET Studies of Mixed Ligand Transition Metal Complexes Based on Novel Schiff Base and 1,10-Phenanthroline. Asian Journal of Chemistry, 37(1), 19–30. https://doi.org/10.14233/ajchem.2025.32196
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