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Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Copyright (c) 2025 Sunil Bakhale, Pushpendra Tiwari

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization and Antimicrobial Evaluation of Aromatic Aldehyde Derivatives of 4-Hydrazinyl-7H-pyrrolo[2,3-d]pyrimidine

https://doi.org/10.14233/ajchem.2025.33044
Sunil C. Bakhale
Department of Chemistry, Mansarovar Global University, Sehore-466111, India
https://orcid.org/0009-0006-0806-7682
Pushpendra Tiwari
Department of Chemistry, Mansarovar Global University, Sehore-466111, India
https://orcid.org/0009-0008-9171-1241

Corresponding Author(s) : Sunil C. Bakhale

sunilc.bakhale@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Abstract

A novel series of pyrrolo[2,3-d]pyrimidine derivatives (2a-j), incorporating a biologically active hydrazone moiety, was synthesized and subjected to antibacterial evaluation. Structural elucidation of the synthesized compounds was achieved using various spectroscopic methods, including IR, 1H and 13C NMR and mass spectrometry. The compounds demonstrated antibacterial and antifungal activities, with MIC values ranging between 50 and 250 µg/mL. The most resistant strains tested were Escherichia coli (MCC 2412), Staphylococcus aureus (MCC 2408), Bacillus subtilis (MCC 2010), Pseudomonas aeruginosa (MCC 2080), Saccharomyces cerevisiae (MCC 1033) and Candida albicans (MCC 1439). All of the compounds showed significant efficacy, according to the antimicrobial screening, with several of them surpassing the common drugs fluconazole and ciprofloxacin.

Keywords

4-Aminopyrrolo[2,3-d]pyrimidine Hydrazine moiety Antibacterial activity Antifungal activity
Bakhale, S. C., & Tiwari, P. (2025). Synthesis, Characterization and Antimicrobial Evaluation of Aromatic Aldehyde Derivatives of 4-Hydrazinyl-7H-pyrrolo[2,3-d]pyrimidine. Asian Journal of Chemistry, 37(2), 355–360. https://doi.org/10.14233/ajchem.2025.33044
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