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Vol. 37 No. 1 (2025): Vol 37 Issue 1, 2025

Copyright (c) 2024 Prakruthi Aiyappa K., Nisha Chiriapanda Lohith, Kadavina Hosahalli Basavaraj Chethan Kumar, Yeriyur B. Basavaraju

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Design, Synthesis and Biological Activities of Thiazolyl-pyrazole-bis-coumarins

https://doi.org/10.14233/ajchem.2025.32981
K. Prakruthi Aiyappa
Department of Studies in Chemistry, Manasagangothri, University of Mysore, Mysore-570006, India
https://orcid.org/0009-0008-2687-4108
Nisha Chiriapanda Lohith
Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysuru-570005, India
https://orcid.org/0000-0002-1261-2640
Kadavina Hosahalli Basavaraj Chethan Kumar
Department of Studies in Chemistry, Manasagangothri, University of Mysore, Mysore-570006, India
https://orcid.org/0009-0001-3554-1064
Yeriyur B. Basavaraju
Department of Studies in Chemistry, Manasagangothri, University of Mysore, Mysore-570006, India
https://orcid.org/0000-0003-4840-7726

Corresponding Author(s) : Yeriyur B. Basavaraju

basavarajuyb2024@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 1 (2025): Vol 37 Issue 1, 2025

Abstract

In this study, we report the synthesis of thiazolyl-pyrazole-biscoumarins employing hydrochloric acid as an effective catalyst. The synthesized derivatives were subjected to biological evaluation for anti-inflammatory, antioxidant and antimicrobial activities. The results indicate that the oxygen containing heterocycles among the synthesized compounds exhibited notable anti-inflammatory and antioxidant properties while sulfur containing heterocycles demonstrated promising antimicrobial efficacy. This work highlights the potential of these thiazolyl-pyrazole-biscoumarin derivatives as multifunctional agents in therapeutic applications.

Keywords

Biscoumarins Anti-inflammatory Sulfur Antimicrobial activity
Aiyappa, K. P., Lohith, N. C., Kumar, K. H. B. C., & Basavaraju, Y. B. (2024). Design, Synthesis and Biological Activities of Thiazolyl-pyrazole-bis-coumarins. Asian Journal of Chemistry, 37(1), 189–194. https://doi.org/10.14233/ajchem.2025.32981
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