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Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Copyright (c) 2025 Vasupavani D, Vaikuntarao L

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Iron Oxide Nanoparticles-Catalyzed Oxidative Cyclization for Synthesis of 2-Substituted Quinazolinones and Benzimidazoles

https://doi.org/10.14233/ajchem.2025.32915
D.V.R. Vasupavani
Department of Chemistry, GITAM School of Sciences, GITAM University, Visakhapatnam-530045, India
https://orcid.org/0009-0001-1561-4094
L. Vaikuntarao
Department of Chemistry, GITAM School of Sciences, GITAM University, Visakhapatnam-530045, India
https://orcid.org/0000-0001-8360-7067

Corresponding Author(s) : D.V.R. Vasupavani

pavanivasu71@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Abstract

Hydrothermally synthesized nanoscale iron(III) oxide (Fe2O3) particles catalyzed the one-pot synthesis of 2-aryl-substituted quinazolinones and benzimidazoles from 2-aminobenzamide and 1,2-diaminoarenes with arylmethane via oxidative cyclization. A key advantage of this method is the use of water as a green solvent, enabling the efficient production of quinazolinones and benzimidazoles in excellent yields, without the need for a base, ligand, or toxic metals. This method is a successful and eco-friendly protocol for synthesizing a wide variety of heterocyclic compounds, and the high surface reactivity of the catalyst is probably a contributing factor.

Keywords

Iron oxide 2-Substituted quinazolinones 2-Substituted benzimidazoles
Vasupavani, D., & Vaikuntarao, L. (2025). Iron Oxide Nanoparticles-Catalyzed Oxidative Cyclization for Synthesis of 2-Substituted Quinazolinones and Benzimidazoles. Asian Journal of Chemistry, 37(2), 275–283. https://doi.org/10.14233/ajchem.2025.32915
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