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Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Copyright (c) 2025 hemalatha kanagarajan, Mrs

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Enantio-Enriched Quinic Acid in Anticancer Agents: A Review

https://doi.org/10.14233/ajchem.2025.32880
Sujaritha Jayaraj
Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai-602105, India
https://orcid.org/0000-0001-7748-5964
Hemalatha Kanagaraj
Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai-602105, India
https://orcid.org/0000-0002-6274-158X

Corresponding Author(s) : Hemalatha Kanagaraj

hemalatha6585@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 2 (2025): Vol 37 Issue 2, 2025

Abstract

An intriguing avenue for cancer treatment has emerged in the form of enantio-enriched quinic acid, which offers a unique perspective on cancer treatment. In this review, chirality is discussed about drug development and its on the pharmacological properties of quinic acid (C7H12O6) derivatives. With enantioselective syntheses, quinic acid enantiomers with distinct stereochemistry can be developed, which leads to different biological interactions. This review also emphasizes the anticancer properties of enantio-enriched quinic acid derivatives, identifying particular enantiomers that exhibit increased bioactivity while minimizing off-target effects. Aside from their potency as potent anticancer agents with diminished adverse effects, these compounds often display favourable pharmacokinetic profiles. However, there are still obstacles to overcome, despite the fact that enantioselective synthesis procedures are both scalable and cost-efficient. For these enantiomer-enriched compounds to be validated as safe and effective, extensive in vivo investigations and clinical trials are essential. In addition to further research, potential synergistic interactions between these drugs and established therapies should be explored.

Keywords

Quinic acid Enantiomers Biosynthesis Anticancer Chirality
Jayaraj, S., & Kanagaraj, H. (2025). Enantio-Enriched Quinic Acid in Anticancer Agents: A Review. Asian Journal of Chemistry, 37(2), 251–265. https://doi.org/10.14233/ajchem.2025.32880
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