Copyright (c) 2024 MAYANK YADAV YADAV, RITA SAINI, Ranjit Singh, Mukesh Maithani
This work is licensed under a Creative Commons Attribution 4.0 International License.
Novel 1,2-Disubstituted Benzimidazole Derivatives: Synthesis and in silico Antibacterial Activity
Corresponding Author(s) : Mayank Yadav
Asian Journal of Chemistry,
Vol. 36 No. 11 (2024): Vol 36 Issue 11, 2024
Abstract
A series of 14 novel 1,2-disubstituted benzimidazole derivatives was synthesized by reacting substituted benzimidazoles with ethyl succinyl chloride and characterized by spectroscopic techniques (FTIR, 1H NMR and Mass). The molecular docking analyses with AutoDock Tools-1.5.7 were used to examine the interactions between the compounds and the active site residues of Topoisomerase-II enzyme (PDB ID: 1JIJ). Amongst the 14 derivatives, 11 derivatives had shown greater binding affinity with the receptor in comparison with standard drug pefloxacin.
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J. Singh, R. Saini and P. Grover, Indian J. Heterocycl. Chem., 21, 185 (2011).
R. Srivastava, S.K. Gupta, F. Naaz, P.S.S. Gupta, M. Yadav, V.K. Singh, A. Singh, M.K. Rana, S.K. Gupta, D. Schols and R.K. Singh, Comput. Biol. Chem., 89, 107400 (2020); https://doi.org/10.1016/j.compbiolchem.2020.107400
M.I. Kharitonova, A.O. Denisova, V.L. Andronova, A.L. Kayushin, I.D. Konstantinova, S.K. Kotovskaya, G.A. Galegov, V.N. Charushin and A.I. Miroshnikov, Bioorg. Med. Chem. Lett., 27, 2484 (2017); https://doi.org/10.1016/j.bmcl.2017.03.100
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S.C. Raka, A. Rahman, F. Hussain and S.A. Rahman, Saudi J. Biol. Sci., 29, 239 (2022); https://doi.org/10.1016/j.sjbs.2021.08.082
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R.F. Khan and M.S. Farooqui, J. Adv. Med. Pharm. Sci., 23, 28 (2021); https://doi.org/10.9734/jamps/2021/v23i530236
K. Gullapelli, G. Brahmeshwari, M. Ravichander, U. Kusuma. Egypt. J. Basic Appl. Sci., 4, 303 (2017); https://doi.org/10.1016/j.ejbas.2017.09.002
C.M.M. Prasada Rao, Bioinformation, 17, 404 (2021); https://doi.org/10.6026/97320630017404
K.M. Orritt, L. Feng, J.F. Newell, J.N. Sutton, S. Grossman, T. Germe, L.R. Abbott, H.L. Jackson, B.K.L. Bury, A. Maxwell, M.J. McPhillie and C.W.G. Fishwick, RSC Med. Chem., 13, 831 (2022); https://doi.org/10.1039/D2MD00049K
X.Y. Meng, H.X. Zhang, M. Mezei and M. Cui, Curr. Computeraided Drug Des., 7, 146 (2011); https://doi.org/10.2174/157340911795677602
O. Trott and A.J. Olson, J. Comput. Chem., 31, 455 (2010); https://doi.org/10.1002/jcc.21334
BIOVIA, Dassault Systemes, Discovery Studio, R2 Client, San Diego: Dassault Systeme (2017); https://www.3ds.com/products/biovia/discovery-studio