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Vol. 36 No. 11 (2024): Vol 36 Issue 11, 2024

Copyright (c) 2024 Udaya Bhaskar Jekkoju

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Synthesis, Characterization and Antibacterial Activity of Some Novel Pyrido[2,3-b]indole, Morpholine and Chalcone Hybrid Compounds

https://doi.org/10.14233/ajchem.2024.32585
J. Udaya Bhaskar
School of Science, GITAM (Deemed to be University), Visakhapatnam-530045, India; Dr. Reddy’s Laboratories Ltd., Srikakulam-532409, India
https://orcid.org/0009-0007-6963-8706
G. Srinivasa Rao
School of Science, GITAM (Deemed to be University), Visakhapatnam-530045, India
https://orcid.org/0000-0001-9647-7206
Pranab Chatterjee
Dr. Reddy’s Laboratories Ltd., Srikakulam-532409, India
https://orcid.org/0009-0002-3848-6432
D.K. Sahoo
Dr. Reddy’s Laboratories Ltd., Srikakulam-532409, India
https://orcid.org/0009-0006-8697-7550
S. Srinivasa Rao
Dr. Reddy’s Laboratories Ltd., Srikakulam-532409, India
https://orcid.org/0009-0001-1530-5072
B. Pulla Rao
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur-522510, India
https://orcid.org/0009-0005-5965-0002

Corresponding Author(s) : J. Udaya Bhaskar

judayabhaskar22@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 11 (2024): Vol 36 Issue 11, 2024

Abstract

In present investigation, a novel series of (E)-3-(2-morpholino-9H-pyrido[2,3-b]indol-3-yl)-1-phenylprop-2-en-1-one and its derivatives (5a-f) were synthesized by condensation reaction from the final intermediate, 2-morpholino-9H-pyrido[2,3-b]indol-3-carbaldehyde (4). The synthesis of the title compounds commenced from commercially available 21H-indol-2-amine (1) and by involving N-(1H-indol-2-yl)-acetamide (2) and 2-chloro-9H-pyrido[2,3-b]indole-3-carbaldehyde (3) as reactive intermediates. The chemical structure of synthesized compounds was characterized by IR, 1H NMR, mass spectral data and elemental analysis. The final compounds were used to screen for their antibacterial activity against various strains of bacteria.

Keywords

Indole Morpholine Pyridines Antibacterial activity
Bhaskar, J. U., Rao, G. S., Chatterjee, P., Sahoo, D., Rao, S. S., & Rao, B. P. (2024). Synthesis, Characterization and Antibacterial Activity of Some Novel Pyrido[2,3-b]indole, Morpholine and Chalcone Hybrid Compounds. Asian Journal of Chemistry, 36(11), 2598–2602. https://doi.org/10.14233/ajchem.2024.32585
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