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Titrimetric Analysis of Some Antituberculous Drugs Using Ammonium Hexanitratocerate(IV) Reagent
Corresponding Author(s) : I.C. Shukla
Asian Journal of Chemistry,
Vol. 25 No. 15 (2013): Vol 25 Issue 15
Abstract
In the present paper we have reported a simple and convenient titrimetric method for determination of antituberculous drugs e.g., cycloserine, ethambutol, isoniazid, pyrazinamide and rifampicin in pure form and in their pharmaceutical preparations such as MD-serine (Tab), pamcerin (Tab), mymbutol (Tab), zytham (Tab), ipcazide (Inj), isokin (Tab), zypra (Tab), P-Zide (Tab), R-Cinex (Tab) and zucox (Tab) with ammonium hexanitratocerate(IV) reagent. It is a versatile oxidizing agent of cerium(IV) and is being widely used as an oxidant for several classes of organic compounds. During estimation it was noted that the excipients present in pharmaceutical preparations do not interfere. The value of percentage error, coefficient of variation (CV) and standard deviation (SD) prove the method to be precise and reproducible. To establish authenticity of the method, recovery experiments were also carried out by standard drug addition method.
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- J.R. Hwu and K.Y. King, Curr. Sci., 81, 1043 (2001).
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- F.J. Wegehaupt, B. Sener, T. Attin and P.R. Schmidlin, Arch. Oral Biol., 55, 441 (2010).
- D.A. Conlon, D. Kumke, C. Moeder, M. Hardiman, G. Hutson and L. Sailer, Adv. Synth. Catal., 346, 1307 (2004).
- C.J. Shih, Y.J. Chen and M.H. Hon, Mater. Chem. Phys., 121, 99 (2010).
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- M.A. Arenas,A. Conde and J.J.D. Damborenea,Corr. Sci., 44, 511 (2002).
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- Indian Pharmacopoeia, Controller of Publication, Govt. of India, Ministry of Health and Family Walfare, New Delhi (2008).
References
J.R. Hwu and K.Y. King, Curr. Sci., 81, 1043 (2001).
M.-I. Lannou, F. Hélion and J.-L. Namy, Tetrahedron, 59, 10551 (2003).
K. Basavaiah, V. Ramakrishna and U.R.A. Kumar, Acta Pharm., 57, 211 (2007).
I.B. Sharma, V. Singh and M. Lakhanpal, J. Thermal Anal., 38, 1345 (1992).
L. Haiping, L. Ning and B. Sifu, J. Rare Earths, 24, 180 (2006).
L.G. Chatten, R.A. Locock and R.D. Krause, J. Pharm. Sci., 60, 588 (1971).
I. Miguel-Garcia, S. Parres-Esclapez, D. Lozano-Castello and A. BuenoLopez, Catal. Commun., 11, 848 (2010).
A.K. Dorai, S. Selvasekarapandian, N. Hellar, S. Ayyasamy and H. Muthusamy, Ionics, 16, 481 (2010).
F.J. Wegehaupt, B. Sener, T. Attin and P.R. Schmidlin, Arch. Oral Biol., 55, 441 (2010).
D.A. Conlon, D. Kumke, C. Moeder, M. Hardiman, G. Hutson and L. Sailer, Adv. Synth. Catal., 346, 1307 (2004).
C.J. Shih, Y.J. Chen and M.H. Hon, Mater. Chem. Phys., 121, 99 (2010).
E.G. Heckert, A.S. Karakoti, S. Seal and W.T. Self, Biomaterials, 29, 2705 (2008).
M.A. Arenas,A. Conde and J.J.D. Damborenea,Corr. Sci., 44, 511 (2002).
M. Wu, Q. Zhang, Y. Liu, Q. Fang and X. Liu, Mater. Res. Bull., 44, 1437 (2009).
T. Arii, T. Taguchi, A. Kishi, M. Ogawa and Y. Sawada, J. Eur. Ceram. Soc., 22, 2283 (2002).
Indian Pharmacopoeia, Controller of Publication, Govt. of India, Ministry of Health and Family Walfare, New Delhi (2008).