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Phase Behaviour of Ternary System: Soybean Oil/Non-Ionic Surfactants/Deionized Water
Corresponding Author(s) : Intan Safinar Ismail
Asian Journal of Chemistry,
Vol. 25 No. 9 (2013): Vol 25 Issue 9
Abstract
Ternary phase diagrams of soybean oil with different types of non-ionic surfactants and deionized water were constructed in order to determine their phase behaviours. The five ternary phase diagrams constructed were: soybean oil/Tween 80/deionized water; soybean oil/Span 20/ deionized water; soybean oil/Cremophor EL/deionized water; soybean oil/Cremophor EL-Tween 80/deionized water and soybean oil/Cremophor EL-Span 20/deionized water. The regions observed from the diagrams were isotropic, homogenous, liquid crystalline, two-phase and multiphase. The area of isotropic and homogenous region increased with the increasing of hydrophilic-lipophilic balance value and also with the presence of co-surfactant. Among those five ternary phase diagrams obtained, the largest one-phase region can be found at the formulation of soybean oil/Cremophor EL-Span 20/deionized water. Cremophor EL has the highest hydrophilic-lipophilic balance value, followed by Tween 80 and Span 20. Larger one-phase region is beneficial because the stability of the components in the mixture is higher if compared to two and multiphase regions.
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- Z. Mei, H. Chen, T. Weng and Y. Yang, Eur. J. Pharm. Biopharm., 56, 189 (2003).
- S. Shafiq, S. Faiyaz, T. Sushma, F.J. Ahmad, R.K. Khar and M. Ali, Eur. J. Pharm. Biopharm., 66, 227 (2007).
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- W.M. Wan Rusmawati, F.B.H. Ahmad, K. Anuar and S. Hamdan, Orient. J. Chem., 16, 393 (2001).
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References
Z. Mei, H. Chen, T. Weng and Y. Yang, Eur. J. Pharm. Biopharm., 56, 189 (2003).
S. Shafiq, S. Faiyaz, T. Sushma, F.J. Ahmad, R.K. Khar and M. Ali, Eur. J. Pharm. Biopharm., 66, 227 (2007).
S.S.A. Gani, M. Basri, M.B.A. Rahman, A. Kassim, A.B. Salleh, R.N.Z.R. Abdul Rahman and Z. Ismail, Tenside Surfact. Deterg., 46, 1 (2009).
A. Azeem, M. Rizwan, F.J. Ahmad, Z. Iqbal, R.K. Khar, M. Aqil and S. Talegaonkar, AAPS Pharm. Sci. Technol., 10, 69 (2009).
P.K. Gosh, J. Majithiya Rita, L.U. Manish and S.R.M. Rayasa, AAPS Pharm. Sci. Technol., 7, E1 (2006).
C. Naresh, B. Henry, F. Lauriane, F. Scanu, R. Siperstein and E.G. Keith, J. Chem. Phys., 122, 1 (2005).
W.M. Wan Rusmawati, F.B.H. Ahmad, K. Anuar and S. Hamdan, Orient. J. Chem., 16, 393 (2001).
A.Z.B. Ismail, N.N.A. Rashid and F.B.H. Ahmad, Orient. J. Chem., 27, 959 (2011).
S. Aviram and A. Abraham, Adv. Colloid Interf. Sci., 128-130, 47 (2006).