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Vol. 31 No. 1 (2019): Vol 31 Issue 1

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Microwave Assisted Synthesis and Antimicrobial Activity of 1-(2-Chloropyridin-3-yl)-3-substituted Urea Derivatives

https://doi.org/10.14233/ajchem.2019.21447
Vijay Kumar Pujari
New Age Life Science, Plot No. 65A&B, Sy. No. 125, Road No. 28, IDA Phase-II, Mallapur, Hyderabad-500076, India
Srilalitha Vinnakota
Department of Chemistry, Faculty of Science and Technology, ICFAI Foundation for Higher Education, Hyderabad-501203, India
Ramana Kumar Kakarla
Department of Chemistry, CMR Institute of Technology, Hyderabad-501401, India
Sridhar Marojua
New Age Life Science, Plot No. 65A&B, Sy. No. 125, Road No. 28, IDA Phase-II, Mallapur, Hyderabad-500076, India

Corresponding Author(s) : Vijay Kumar Pujari

pujarivijaykumar7@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 1 (2019): Vol 31 Issue 1

Abstract

A green one pot synthetic protocol method for 1-(2-chloropyridin-3-yl)-3-substituted urea derivatives from 2-chloropyridin-3-amine and tert-butyl substituted carbamates by using bis(trimethylaluminum)-1,4-diazabicyclo[2,2,2]octane (DABAL-Me3) under microwave irradiation is developed. The compound structures established by spectral data such as IR, 1H NMR and mass spectroscopy. All the synthesized compounds were tested in vitro antimicrobial activity.

Keywords

2-Chloropyridinyl urea derivatives Microwave irradiation method Antimicrobial activity
Pujari, V. K., Vinnakota, S., Kakarla, R. K., & Marojua, S. (2018). Microwave Assisted Synthesis and Antimicrobial Activity of 1-(2-Chloropyridin-3-yl)-3-substituted Urea Derivatives. Asian Journal of Chemistry, 31(1), 41–44. https://doi.org/10.14233/ajchem.2019.21447
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