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Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015

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A Green Approach to Synthesize Dihydropyrimidinone Derivatives by Using Anhydrous ZnCl2 Catalyst Under Refluxing Condition in Heptane-Toluene Medium via Biginelli Reaction

https://doi.org/10.14233/ajchem.2015.18615
Kawsari Akhter
Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
Khorshada Jahan
Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
U.K.R. Romman
Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
M. Giasuddin Ahmed
Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
Md. Sharifur Rahman
Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
Md. Al-Amin
Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh

Corresponding Author(s) : Kawsari Akhter

kawsariakhter@yahoo.com

Asian Journal of Chemistry, Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015

Abstract

Aldehydes, 1a-g (1a, Ar = 4-Cl-C6H4, 1b, Ar = 4-CH3-C6H4, 1c, Ar = 2-Cl-C6H4, 1d, Ar = 2-CH3- C6H4, 1e, Ar = -C6H5, Ar = 4-Cl-C6H4, 1g, Ar = 2-Cl-C6H4) reacted with acetylacetone 2a and urea/thiourea 3a-b in the presence of anhydrous zinc chloride under refluxing condition in heptane-toluene medium to give the corresponding 5-aceto-4-aryl-6-methyl-2-oxo-1,2,3,4-tetrahydropyridimidine 4a-d and 5-aceto-4-aryl-6-methyl-2-thio-1,2,3,4-tetrahydropyridimidine 4e-g. The structure of the compounds 4a-g were confirmed by their UV, IR, 1H NMR and 13C NMR analysis.

Keywords

Aldehydes Acetylacetone Urea/thiourea Dihydropyrimidinones Biginelli reaction
Akhter, K., Jahan, K., Romman, U., Giasuddin Ahmed, M., Sharifur Rahman, M., & Al-Amin, M. (2015). A Green Approach to Synthesize Dihydropyrimidinone Derivatives by Using Anhydrous ZnCl2 Catalyst Under Refluxing Condition in Heptane-Toluene Medium via Biginelli Reaction. Asian Journal of Chemistry, 27(7), 2624–2626. https://doi.org/10.14233/ajchem.2015.18615
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