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Vol. 31 No. 8 (2019): Vol 31 Issue 8

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Isolation and Characterization of Secondary Metabilites and Evaluation of Antimicrobial, Antioxidant and Thrombolytic Potentials of Erythrina variegata L. Bark

https://doi.org/10.14233/ajchem.2019.21993
Fatema Tabassum
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
https://orcid.org/0000-0001-5299-5482
Choudhury Mahmood Hasan
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
Mohammad Mehedi Masud
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
Md. Imran Nur Manik
Department of Pharmacy, Northern University Bangladesh, Dhaka-1205, Bangladesh
Monira Ahsan
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

Corresponding Author(s) : Fatema Tabassum

fatematabassum23@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 8 (2019): Vol 31 Issue 8

Abstract

Six compounds, sitosta-4-en-3-one (1), 3β,28-dihydroxyolean-12-en (2), scandenone (3), alpinum isoflavone (4), stigmasterol (5) and lupeol (6) were isolated from the methanol soluble extract of the stem bark of Erythrina variegata. The structure of the compounds was established by extensive NMR studies as well as co-TLC with authentic sample. The petroleum ether, carbon tetrachloride, chloroform and aqueous soluble fractions of the methanolic extract of Erythrina variegata were evaluated for antimicrobial, antioxidant and thrombolytic properties. In the antimicrobial study, most of the fractions of the extract exhibited mild to moderate antimicrobial activity where the zone of inhibition were ranging from 7.69 to 19.51 mm. The chloroform soluble fraction showed significant antioxidant activity with IC50 value 66.28 μg/mL as compared to standard BHT (IC50 value 23.09 μg/mL). The thrombolytic property of different extracts of E. variegata exhibited moderate activity ranging from 31.25 to 57.78 %.

Keywords

Erythrina variegata Isoflavone Triterpene Sitosta-4-en-3-one Antibacterial Antioxidant Thrombolytic
Tabassum, F., Hasan, C. M., Masud, M. M., Nur Manik, M. I., & Ahsan, M. (2019). Isolation and Characterization of Secondary Metabilites and Evaluation of Antimicrobial, Antioxidant and Thrombolytic Potentials of Erythrina variegata L. Bark. Asian Journal of Chemistry, 31(8), 1842–1846. https://doi.org/10.14233/ajchem.2019.21993
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